Possible Interaction: Calcitonin Gene-Related Peptide and Melatonin

“ Melatonin has been shown to regulate CGRP and control its release.”

“It is also possible that abnormal melatonin secretion leads to decreased inhibitory neurotransmitter activity, decreased inhibition of the release of calcitonin gene-related peptide (CGRP) from activation of the trigeminal system, or less analgesia.”

“We found that melatonin treatment significantly decreases mRNA expression of CGRP release, NO production, and iNOS activity in the patient groups.”

“Interestingly, blocking oxidative stress by administering melatonin (MT) not only reduced oxidative stress and CGRP levels, but also ameliorated the asthmatic symptoms.”

“We conclude that (1) exogenous melatonin and that derived from its precursor, L‐tryptophan, accelerate ulcer healing probably via interaction with MT2 receptors; (2) … and NO because of overexpression of iNOS and (3) gastrin, which exhibits trophic activity in the gastric mucosa and calcitonin gene related peptide CGRP), … melatonin.”

“In addition, CGRP (10(-7) M)-mediated increase in adenylate cyclase activity was also significantly attenuated by the receptor mediated action of melatonin.”

“These results indicate that melatonin may interact with CGRP to regulate cerebral arterial tone.”

“Immunofluorescence analysis also confirmed that MT inhibited CGRP and IB4 expression of TG neurons, and this inhibition was reversed by administering the MT2R antagonist in TMJOA rats.”

“Interestingly, melatonin not only markedly decreased the protein levels of TRPV1 and CGRP , but also enhanced the expression of Nrf2, quinone oxidoreductase-1 (NQO-1), and heme oxygenase-1 (HO-1).”