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Last Updated: 2 years ago

Possible Interaction: Calcitonin Gene-Related Peptide and Melatonin

Research Papers that Mention the Interaction

Melatonin has been shown to regulate CGRP and control its release.
Cephalalgia : an international journal of headache  •  2019  |  View Paper
It is also possible that abnormal melatonin secretion leads to decreased inhibitory neurotransmitter activity, decreased inhibition of the release of calcitonin gene-related peptide (CGRP) from activation of the trigeminal system, or less analgesia.
CNS drugs  •  2006  |  View Paper
We found that melatonin treatment significantly decreases mRNA expression of CGRP release, NO production, and iNOS activity in the patient groups.
Acta Neurologica Belgica  •  2017  |  View Paper
Interestingly, blocking oxidative stress by administering melatonin (MT) not only reduced oxidative stress and CGRP levels, but also ameliorated the asthmatic symptoms.
Ecotoxicology and environmental safety  •  2020  |  View Paper
We conclude that (1) exogenous melatonin and that derived from its precursor, L‐tryptophan, accelerate ulcer healing probably via interaction with MT2 receptors; (2) … and NO because of overexpression of iNOS and (3) gastrin, which exhibits trophic activity in the gastric mucosa and calcitonin gene related peptide CGRP), … melatonin.
Journal of pineal research  •  2002  |  View Paper
In addition, CGRP (10(-7) M)-mediated increase in adenylate cyclase activity was also significantly attenuated by the receptor mediated action of melatonin.
These results indicate that melatonin may interact with CGRP to regulate cerebral arterial tone.
European journal of pharmacology  •  2001  |  View Paper
Immunofluorescence analysis also confirmed that MT inhibited CGRP and IB4 expression of TG neurons, and this inhibition was reversed by administering the MT2R antagonist in TMJOA rats.
Journal of dental research  •  2021  |  View Paper
Interestingly, melatonin not only markedly decreased the protein levels of TRPV1 and CGRP , but also enhanced the expression of Nrf2, quinone oxidoreductase-1 (NQO-1), and heme oxygenase-1 (HO-1).
Environmental Science and Pollution Research  •  2021  |  View Paper