Possible Interaction: Calcitonin Gene-Related Peptide and Glucose

“In pithed rats with artificially increased blood pressure and blockade of autonomic outflow, glucose infusion attenuated CGRPergic nerve-depressor responses to SCS without affecting depressor responses to injection of CGRP, acetylcholine or SNP.”

“Moreover, intravenous infusion of CGRP decreased tolerance to intragastric administration of glucose (O-GTT) without altering plasma insulin levels, but again IAPPs had no effect.”

“CGRP was infused at 100 pmol.kg-1.min-1 during the last 90 min … insulin clamp study and determined a rise in plasma concentration to 781 +/- 34 pM. Hepatic glucose production was stimulated … infusion of CGRP (35.6 +/- 6.1 vs. 24.….4 mumol.kg-1.min-1).”

“Furthermore, exogenously administered CGRP and SP attenuated the myocyte injury induced by the high concentration of glucose and hypoxia/reoxygenation.”

“In pithed rats with artificially increased blood pressure and blockade of autonomic outflow, glucose infusion attenuated CGRPergic nerve−depressor responses to SCS without affecting depressor responses to injection of CGRP, acetylcholine or SNP.”

“ CGRP antagonized insulin's suppression of hepatic glucose production at plasma concentrations (approximately 10(-10) M) that are only two- to fivefold its basal portal concentration.”

“It was found that insulin secretion stimulated by glucose (8.3 mM) was inhibited by 77% by CGRP at 10(-6) M (p less than 0.001) and by 48% by the peptide at 10(-7) M (p less than 0.05).”

“On the other hand, intravenous infusion of CGRP (46.6 pmol · kg−1 · min−1) decreased tolerance to intragastric administration of glucose (IGGTT).”

“In contrast, CGRP impaired the plasma insulin responses to both glucose (7 mg/min; P less than 0.001) and arginine (8.5 mg/min; P less than 0.001), and inhibited the arginine-induced increase in plasma glucagon concentrations (P less than 0.001).”