Possible Interaction: Calcitonin Gene-Related Peptide and Epinephrine

“ CGRP inhibited platelet aggregation in vitro in 19 of the subjects (90.5%) in a dose-dependent manner with 50% inhibitory doses of 1.6 mumol/L and 1.1 mumol/L for aggregation induced by epinephrine and collagen, respectively.”

“ CGRP lowered diastolic blood pressure by 26% and increased the heart rate by 35% and raised plasma levels of norepinephrine, epinephrine , and dopamine and renin activity (P less than 0.01).”

“ hCGRP (545 pmol/min) caused the diastolic pressure to fall from 64 +/- 5 to 55 +/- 7 mmHg (P less than 0.05), the heart … 34.9 +/- 0.5 degrees C. Plasma noradrenaline increased from 481 +/- 126 to 835 +/- 65 pg/ml (P less than 0.05) and plasma adrenaline …).”

“Central administration of CGRP activates the hypothalamo–pituitary– adrenal axis resulting in increased corticosterone secretion.”

“In the capsule this vasoconstriction was virtually abolished when CGRP (10−9 mol) was co‐administered with adrenaline but in the ligament vasodilatation occurred at all sites.”

“Injections of CGRP into laminae V-VI decreased significantly the adrenal secretion of epinephrine , however, other measured variables were not affected.”

“Microinjections of CGRP (5 pmol, 100 nl) into laminae I-II increased significantly the adrenal secretion of epinephrine , adrenal blood flow, adrenal vascular conductance, mean arterial pressure and heart rate.”

“Moreover, although intravenous injection of CGRP (5.67 nmol/kg) elicited a significant increase in plasma epinephrine and norepinephrine concentrations, concomitant administration of epinephrine and norepinephrine, inducing a more prominent rise in plasma catecholamines than those induced by CGRP, affected neither plasma glucose nor insulin levels.”

“ CGRP increased plasma norepinephrine, epinephrine , and renin activity significantly at only the 2200-pmol dose.”