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Last Updated: 2 years ago

Possible Interaction: Caffeine and Zolpidem



Research Papers that Mention the Interaction

As zolpidem, a short-acting hypnotic, is an atypical GABAA-BZD agonist, we investigated when caffeine would counteract the effects of zolpidem as well.
European Journal of Clinical Pharmacology  •  1998  |  View Paper
It is proposed that by modifying the cellular redox state, caffeine ultimately reduces the pool of reactive oxygen species, thereby increasing the bioavailability of endogenous melatonin for interaction with zolpidem.
Paradoxically, in some cases caffeine appears to slightly enhance zolpidem sedation.
Current drug targets  •  2009  |  View Paper
Zolpidem attenuated the caffeine-induced decrease in SE and increased spindle density in the caffeine plus zolpidem combination compared with placebo.
Journal of psychopharmacology  •  2009  |  View Paper
Caffeine coadministration modestly increased maximum plasma concentration (Cmax) and area under the plasma concentration‐time curve of zolpidem by 30–40%, whereas zolpidem did not significantly affect the pharmacokinetics of caffeine or its metabolites.
Caffeine partially , but not completely, reversed most pharmacodynamic effects of zolpidem.
Thus, caffeine only incompletely reverses zolpidem's sedative and performance‐impairing effects, and cannot be considered as an antidote to benzodiazepine agonists.
Clinical pharmacology and therapeutics  •  2007  |  View Paper
In combination, zolpidem attenuated caffeine ’s effects on WAKE, whilst trazodone attenuated its effects on NREM sleep, NREM bout duration, delta activity, body temperature and locomotor activity.
Journal of psychopharmacology  •  2009  |  View Paper