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Discover Supplement-Drug Interactions
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Last Updated: 5 years ago
Research Papers that Mention the Interaction
“Diltiazem (10 μmol/L) and verapamil (10 μmol/L) inhibited the hypercontractility induced by 3% halothane and 2 mmol/L caffeine in malignant hyperpyrexia susceptible (MHS) muscle.”
EFFECT OF DILTIAZEM, VERAPAMIL AND DANTROLENE ON THE CONTRACTILITY OF ISOLATED MALIGNANT HYPERPYREXIA‐SUSCEPTIBLE HUMAN SKELETAL MUSCLE“The positive inotropic and the arrhythmogenic effects of caffeine could be diminished by pretreating the fibres with propranolol or Ca antagonists (diltiazem and verapamil).”
“Application of 10 μm verapamil to the bath led to 30% and 52% reductions in the Ca2+ leak caused by the presence of caffeine for the peak and steady-state values of net Ca2+ fluxes, respectively.”
“The effects of Ca2+ channel blockers verapamil and gadolinium) were explored using 6 mm caffeine; both significantly reduced the action of caffeine on tension and on calcium fluxes.”
Effects of Verapamil and Gadolinium on Caffeine-Induced Contractures and Calcium Fluxes in Frog Slow Skeletal Muscle Fibers“The spontaneous rhythmic activity and a phasic contraction induced by caffeine , were blocked by verapamil (3 microM) or by removal of external Ca2+.”
“Pretreatment with verapamil (1 or 10 μm), nifedipine (0.1 μm) or incubation with Ca2+‐free, EGTA (0.1 mm)‐containing physiological salt solution (PSS) suppressed the contraction produced by caffeine or theophylline in PDA (5 μm)‐treated tissues.”
“ Verapamil (10 μm) prevented the effects of PDA against caffeine‐ or theophylline‐induced relaxation.”
“At 37 degrees C caffeine induced a phasic contraction and the contraction was inhibited by verapamil or in the absence of Ca.”
“ Caffeine (5 mM)-induced contraction in the presence of verapamil and phentolamine was significantly smaller in SHR than in WKY.”
“ Verapamil and manganese inhibited 4-AP, caffeine and quinine-induced contractures.”
“The spasmogenic activity of caffeine (10 mM) was evaluated in tracheal strips obtained from … (2.8 microM) and cooled to 20 degrees C. The contraction elicited by caffeine … verapamil (100 microM), trifluoperazine (100 and 500 microM) and dantrolene (50 … sensitized tissues but was unaffected by disodium cromoglycate (39 microM).”
“However, the potentiating effect of caffeine was not abolished by verapamil.”
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