“As a result, caffeine inhibits the antinociceptive effect of venlafaxine in acute application in mice and this observation provides new evidence that the adenosinergic system may play a significant role in the mechanism of antinociceptive action of venlafaxine.”
“ Caffeine alone showed no significant antinociceptive effect at the applied dose however, it significantly antagonized the antinociceptive effect of venlafaxine at 30 min.”
“This study raises the possibility that caffeine consumption might influence the effectiveness of venlafaxine in the treatment of pain in humans.”