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Last Updated: 2 years ago

Possible Interaction: Caffeine and Valproic Acid

supplement:

Caffeine

Research Papers that Mention the Interaction

We have also reported the anti-tumor efficacy of combination treatment with caffeine and valproic acid against osteosarcoma primary tumors in a cell-line orthotopic mouse model.
Anticancer research  •  2017  |  View Paper
Interestingly, animal data have demonstrated that caffeine , at doses far below its convulsive potential, diminishes the protective effects of conventional antiepileptic drugs (AEDs--carbamazepine, phenobarbital, phenytoin, valproate ) and the newer AED, topiramate against electroconvulsions in mice.
Pharmacological reports : PR  •  2011  |  View Paper
Acute caffeine , in doses far below its convulsive potential (almost 10-20 fold lower than the ED50 of the methylxanthine of 2.… mmol/kg for the induction of seizures), produced a significant reduction in the anticonvulsant effects of carbamazepine, phenobarbital, phenytoin, and valproate against maximal electroshock-… seizures in mice.
Przeglad lekarski  •  2007  |  View Paper
Both VPA and CAF caused concentration-dependent cell death of the osteosarcoma cell lines in vitro, and their combination was synergistic.
The IC50 for CAF for AC-UPS01 was 2.02 ± 0.22 mM. The IC50 for VPA for AC-UPS01 was 9.54 ± 1.….37 ± 0.48 mM. The IC50 for VPA for AC-RMS01 was 2.13 ± 0.20 mM. Synergistic efficacy of combination treatment of CAF … VPA ….
Anticancer research  •  2017  |  View Paper
Caffeine has been reported to be proconvulsant and to reduce the anticonvulsant efficacy of a variety of antiepileptic drugs (carbamazepine, phenobarbital, phenytoin, valproate and topiramate) in animal models of epilepsy and to increase seizure frequency in patients with epilepsy.
Pharmacological reports : PR  •  2009  |  View Paper
The ED50, for VPA was significantly increased both by the single dose of caffeine and by chronic treatment.
Epilepsia  •  1996  |  View Paper
SV and ESM showed a qualitative departure in their anti-seizure activity profiles following interaction with either AMP or CAF when compared with the other AEDs.
Indian journal of experimental biology  •  1991  |  View Paper
In doses of 0.238 and 0.476 mmol/kg, caffeine also diminished the efficacy of CBZ and VPA , and at the highest dose tested the methylxanthine elevated the respective ED50s from 13 to 20.5 mg/kg and from 270 to 420 mg/kg.
Epilepsia  •  1990  |  View Paper