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Last Updated: 2 years ago

Possible Interaction: Caffeine and Urethane

supplement:

Caffeine

Research Papers that Mention the Interaction

A tendency for inhibition was evident when caffeine was administered 6 h after urethan but this was also not statistically significant.
Carcinogenesis  •  1981  |  View Paper
In confirmation of previous reports by other investigators, administration of caffeine concurrently with ethyl carbamate inhibited the formation of lung adenomas in A/J mice; no consistent inhibition was obtained under the same conditions when vinyl carbamate or ethyl N -hydroxycarbamate was the carcinogen.
Cancer research  •  1980  |  View Paper
Nomura 1976, 1978, …-treatment with caffeine suppressed lung tumorigenesis induced in … nitroquinoline-l-oxide (4NQO) or urethane , supporting the hypothesis of Kondo (1971, 1977) that caffeine may suppress 4NQOinduced carcinogenesis in mice in … to the diminution of 4NQO-induced mutagenesis in Escherichia coli by inhibition of misrepair in DNA.
British Journal of Cancer  •  1980  |  View Paper
The lungs of Day 15 mouse fetuses treated either with 4NQO or urethan were sensitive to the antineoplastic action of caffeine for only 1.5 days.
Cancer research  •  1980  |  View Paper
Also, caffeine partially antagonized the effects of urethan on lung tissue, as measured by [3H]thymidine incorporation studies.
The most pronounced suppression of lung tumor formation occurred when caffeine was given as only two injections 3 hr before and 3 hr after urethan administration.
The same caffeine injection scheme suppressed urethan (0.25 and 1.0 mg/g)-induced lung tumor development when caffeine treatment started 1 week before urethan administration, but this suppression was not significant when caffeine treatment was initiated 1 week after urethan injection.
Cancer research  •  1978  |  View Paper