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Discover Supplement-Drug Interactions

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Last Updated: 7 months ago

Possible Interaction: Caffeine and Trihexyphenidyl



Research Papers that Mention the Interaction

4 Consistent with these mechanisms, caffeine potentiates the anticholinergic agent trihexyphenidyl in reversing haloperidol-induced catalepsy in rats.
Hong Kong medical journal = Xianggang yi xue za zhi  •  2006  |  View Paper
Although the combined administration of caffeine plus trihexyphenidyl showed no synergism in these models, the results suggest that low doses of caffeine (1-3 mg/kg/day) could be of therapeutic value for the reversal of motor symptoms in parkinsonian patients.
Pharmacology Biochemistry and Behavior  •  2007  |  View Paper
Hence, these results support the proposal that low, subthreshold doses of caffeine plus THP have the potential to alleviate the motor disabilities in parkinsonian patients, with a low risk of causing anxiety or memory impairment.
However, the combination of caffeine plus THP restored locomotion (141 +/- 19%) and vertical exploration (82 +/- 17%) to levels not significantly different to those of non-reserpinized rats.
Since caffeine enhances the potency of THP to inhibit haloperidol-induced catalepsy, caffeine may be used as an adjuvant of lower doses of THP, in order to improve its antiparkinsonian effects without causing memory disruption.
Neuroscience Letters  •  2004  |  View Paper