Possible Interaction: Caffeine and Trifluoperazine

“Abstract The cataleptic action in mice of the neuroleptics bulbocapnine haloperidol and trifluoperazine was increased by the convulsant drugs bemegride, nikethamide, pentylenetetrazol and caffeine.”

“Binding studies in the presence of pharmaceutically relevant drugs indicated that warfarin, paracetamol, and caffeine negatively influenced the binding of trifluoperazine on BSA.”

“Studies on myofibrillar ATPase activity suggest that the stimulating effect of TFP is not identical in its underlying action with those of caffeine and quercetin, which are also known as Ca2+‐sensitizing drugs, having a similar eventual effect on tension development.”

“The spasmogenic activity of caffeine (10 mM) was evaluated in tracheal strips obtained from control … indomethacin (2.8 microM) and cooled to 20 degrees C. The contraction elicited by caffeine …), trifluoperazine (100 and 500 microM) and dantrolene (50 and 500 … tissues but was unaffected by disodium cromoglycate (39 microM).”

“ Trifluoperazine , which had only a small effect on cell survival of cells treated with ADR alone, potentiated killing when cells were treated with ADR in the presence of caffeine.”

“Results from this study indicate that CAF markedly reduces the cytotoxicity of ADR or AD32 and trifluoperazine circumvents the effects of CAF.”

“ Caffeine antagonized the depressant effect on the firing of cortical neurons observed with larger applications of trifluoperazine.”

“Pretreatment with trifluoperazine , an inhibitor of calmodulin-dependent enzyme activation, converted the stimulatory effect of caffeine to the expected inhibitory action.”