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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Caffeine
drug:
Topiramate
Research Papers that Mention the Interaction
“ Caffeine reduces the efficacy of several anti-seizure medications, especially topiramate.”
The Use of Caffeine by People with Epilepsy: the Myths and the Evidence“ Caffeine lowers the efficacy of several drugs, especially topiramate.”
“Interestingly, animal data have demonstrated that caffeine , at doses far below its convulsive potential, diminishes the protective effects of conventional antiepileptic drugs (AEDs--carbamazepine, phenobarbital, phenytoin, valproate) and the newer AED, topiramate against electroconvulsions in mice.”
“In case of newer antiepileptics, both acute and chronic caffeine decreased the protective potential of gabapentin and topiramate but not that of lamotrigine and tiagabine.”
“RESULTS Ca feine (b oth acute and chronic at 23.1 and 46.2mg/kg) significantly reduced the protective effects of TPM ag ainst MES.”
Influence of caffeine on the protective activity of gabapentin and topiramate in a mouse model of generalized tonic-clonic seizures.“ Caffeine has been reported to be proconvulsant and to reduce the anticonvulsant efficacy of a variety of antiepileptic drugs (carbamazepine, phenobarbital, phenytoin, valproate and topiramate ) in animal models of epilepsy and to increase seizure frequency in patients with epilepsy.”
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