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Last Updated: 2 years ago

Possible Interaction: Caffeine and Thiotepa

supplement:

Caffeine

Research Papers that Mention the Interaction

A fixed rotation of TM and CAF resulted in longer survival (median of 15 months and 75th percentile of 27 months) than sequential treatment with TM initially, followed by CAF upon failure (median of 12 months and 75th percentile of 22 months).
The … of TM … CAF also increased progression‐free survival (median of 12 months and 75th percentile of 24 months) over that achieved by initial treatment with TM (… of 6 months and 75th percentile of 15 months) or L‐PAM (median of 9 months and 75th percentile of 21 months).
Cancer  •  1985  |  View Paper
With human bladder cancer … culture, cytotoxicity of thiotepa was increased up to 10-fold (P less than 0.01) … with pentoxifylline, with a major clinical metabolite of pentoxifylline, or with caffeine ; the pentoxifylline concentrations required (0.4-1.0 mM) … clinically achievable in the bladder after nontoxic p.o.
Cancer research  •  1988  |  View Paper
In bean roots a 5-h post-treatment with 2.5 ·10 −3 M caffeine produced an almost 8-fold increase of the thiotepa-induced aberration frequency when given at 25° and 5 h after thiotepa.
Mutation research  •  1974  |  View Paper
Caffeine was found to enhance SCE and breakage frequencies induced by Thiotepa in human lymphocytes.
Experientia  •  2005  |  View Paper
Nontoxic concentrations of two methylxanthines, theobromine and caffeine , markedly enhanced lethality in T-24 human bladder cancer cells treated with thiotepa.
The Journal of urology  •  1984  |  View Paper