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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Caffeine
drug:
Thiopental
Research Papers that Mention the Interaction
“A strong correlation (r = .69; P < .01) was found between the aVd of caffeine and the anesthetic induction dose of thiopental when the loss of eyelid reflex was used as the end point.”
Correlation Between Thiopental Induction Dose and the Volume of Distribution of Caffeine in Human Subjects“Although in calcium-free solution thiopental (100 microg/mL) did not contract aortic rings, it abolished the contractile effect of either phenylephrine (10(-6) M) or caffeine (10 mM).”
“The increase in intracellular Ca2+ concentration elicited by thiopental in Ca2+-free solution and its ability to block the effect of phenylephrine and caffeine suggest that this barbiturate can deplete intracellular pools of calcium.”
Relationship between extra and intracellular sources of calcium and the contractile effect of thiopental in rat aorta.“ Thiopentone , at concentrations over 10−4 M, inhibited the KCl-induced contractions in normal bathing fluid and those induced by caffeine in Ca++-free fluid and, at concentrations over 3 × 10−4 M, inhibited norepinephrine-induced contractions in normal and Ca++-free bathing fluids significantly.”
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