Possible Interaction: Caffeine and Theobromine

“Considering animal studies, it … that acute exposition to theobromine has a reduced and … with respect to caffeine , whereas both animal and human studies suggested a potential neuroprotective action of long-term assumption of … a reduction of Aβ amyloid pathology, which is commonly observed in Alzheimer’s disease patients’ brains.”

“Specific sets of constituent compounds such as polyphenols, theobromine and L‐theanine appear to enhance mood and cognition effects of caffeine and alleviate negative psychophysiological effects of caffeine.”

“The current American Society of Nuclear Cardiology (ASNC) imaging guidelines 5 recommend that caffeine and other methylxanthines (such as aminophylline or theobromine ) be withheld for at least 12 hours prior to vasodilator stress MPI and list this as a contraindication for performing the test.”

“Guarana has been used for centuries as a stimulant in South America, due to its high caffeine content; it also contains xanthine alkaloids, such as theobromine and theophylline, which enhance the effects of caffeine.”

“The combination of theobromine and caffeine , methylxanthines found in chocolate, has previously been shown to improve mood and cognition.”

“This study tested the hypothesis that a combination of caffeine and theobromine has synergistic effects on cognition, mood and blood pressure in 24 healthy female subjects.”

“Guarana, which contains caffeine in addition to small amounts of theobromine , theophylline, and tannins, is also recognized as safe by the FDA, although it may lead to caffeine toxicity when combined with caffeine.”

“ Caffeine interfered with the Vision, Seralyzer, and AccuLevel methods, and theobromine interfered with the Vision, Seralyzer, and TheoFAST methods.”

“Both doses of theacrine could significantly prolong the sleeping time induced by pentobarbital, while caffeine and theobromine exhibited an inverted effect.”

“These results indicate that mixtures of theobromine and caffeine have the potential to be developed into a selective, effective, and socially acceptable toxicant for the control of pest coyotes.”

“In the shuttle avoidance, up to 3 mg/kg of caffeine , and 10 and 30 mg/kg of theophylline or theobromine significantly increased the response rate, though there was no significant change in the avoidance rate at any doses of these methylxanthines.”