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Possible Interaction: Caffeine and Theobromine

supplement:

Caffeine

Research Papers that Mention the Interaction

The current American Society of Nuclear Cardiology (ASNC) imaging guidelines 5 recommend that caffeine and other methylxanthines (such as aminophylline or theobromine ) be withheld for at least 12 hours prior to vasodilator stress MPI and list this as a contraindication for performing the test.
Journal of Nuclear Cardiology  •  2012  |  View Paper
Guarana has been used for centuries as a stimulant in South America, due to its high caffeine content; it also contains xanthine alkaloids, such as theobromine and theophylline, which enhance the effects of caffeine.
British journal of sports medicine  •  2011  |  View Paper
The combination of theobromine and caffeine , methylxanthines found in chocolate, has previously been shown to improve mood and cognition.
This study tested the hypothesis that a combination of caffeine and theobromine has synergistic effects on cognition, mood and blood pressure in 24 healthy female subjects.
Physiology & Behavior  •  2011  |  View Paper
Guarana, which contains caffeine in addition to small amounts of theobromine , theophylline, and tannins, is also recognized as safe by the FDA, although it may lead to caffeine toxicity when combined with caffeine.
The Physician and sportsmedicine  •  2010  |  View Paper
A two-week period of dietary abstention from methylxanthines shortened the mean plasma TB t1/2 by 33% and increased the mean MCR of TB by 59%, no change occurred in mean aVd of TB.
Clinical pharmacology and therapeutics  •  1978  |  View Paper
Theobromine , and the metabolite 3-methylxanthine interfere.
Clinica chimica acta; international journal of clinical chemistry  •  1976  |  View Paper
Caffeine and theobromine cross-reacted slightly.
Analytical biochemistry  •  1981  |  View Paper
Considering animal studies, it … that acute exposition to theobromine has a reduced and … with respect to caffeine , whereas both animal and human studies suggested a potential neuroprotective action of long-term assumption of … a reduction of Aβ amyloid pathology, which is commonly observed in Alzheimer’s disease patients’ brains.
Psychopharmacology  •  2019  |  View Paper
Specific sets of constituent compounds such as polyphenols, theobromine and L-theanine appear to enhance mood and cognition effects of caffeine and alleviate negative psychophysiological effects of caffeine.
Progress in Neuro-Psychopharmacology and Biological Psychiatry  •  2018  |  View Paper
Both doses of theacrine could significantly prolong the sleeping time induced by pentobarbital, while caffeine and theobromine exhibited an inverted effect.
Journal of Asian natural products research  •  2007  |  View Paper
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