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Discover Supplement-Drug Interactions
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Last Updated: 2 years ago
supplement:
Caffeine
drug:
Tetrodotoxin
Research Papers that Mention the Interaction
“Addition of tetrodotoxin (TTX) (10(-7) M) in the presence of caffeine (10 mM) also abolished the dysrhythmia and increased the sinus rate.”
Positive and negative chronotropic effects of caffeine in spontaneously beating rabbit sino-atrial node cells.“… caffeine in a dose-dependent manner 1) shifts … in the presence of agents (local anesthetics, tetrodotoxin , high potassium) that have been shown to diminish the force of contraction, presumably by decreasing cellular calcium, … of veratridine, and 8) fails to induce a marked tail in the presence of metabolic inhibitors.”
“In high [Ca]0 or low [Na]0, caffeine had a predominantly negative inotropic effect which also was reversed by adding tetrodotoxin or by high [K]0.”
“The oscillations were reduced markedly by 0.03-3.0 microM tetrodotoxin (TTX) and were blocked by 5-10 mM caffeine.”
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