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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Caffeine
drug:
Tetraethylammonium
Research Papers that Mention the Interaction
“Spontaneous currents, ICAF and ICCh were blocked with tetraethylammonium at 3 x 10(-4)-10(-2) M but were resistant to both charybdotoxin (10(-7)-10(-6) M) and iberiotoxin (10(-7)-10(-6) M).”
The properties of caffeine- and carbachol-induced intracellular Ca2+ release in mouse bladder smooth muscle cells.“6 Externally applied tetraethylammonium ions (TEA, 3–10 mM) reversibly inhibited unitary Ca2+‐activated K+ currents and STOCs in endothelial cells but failed to inhibit completely the outward current evoked by 20 mM caffeine.”
“6 Tetraethylammonium (3 mM) applied to the bathing solution blocked unitary and spontaneous transient outward currents (STOCs) stimulated by Ca2+‐free solution, but only reduced the outward current evoked by caffeine (20 mM).”
“The Icaffeine was not blocked by apamin and 4-aminopyridine but suppressed by charybdotoxin, tetraethylammonium , quinine and Ba2+.”
“ Caffeine blocked the tetraethylammonium-sensitive slowly activating and inactivating outward current by 32% and the 4-aminopyridine-sensitive rapidly activating and inactivating transient outward current by 19%.”
“The hyperpolarizing potentials were sensitive to blockade by tetraethylammonium and Ba2+, while caffeine increased then abolished these events.”
“ Tetraethylammonium ions (1-10 mM) reversibly blocked the spontaneous potentials, while caffeine (10 mM) increased the frequency of these events.”
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