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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Caffeine
drug:
Tetracaine
Research Papers that Mention the Interaction
“The Ca2+-induced Ca2+ release blocker tetracaine inhibited the rise in [Ca2+]i induced by both caffeine and ATP, with apparent inhibitory constants of 70 μM and 100 μM, respectively.”
Mechanism of the ATP-induced rise in cytosolic Ca2+ in freshly isolated smooth muscle cells from human saphenous vein“In HBSM strips, caffeine induced a transient contraction which, likewise, was inhibited by ryanodine and tetracaine.”
“While tetracaine inhibits sperm motility and caffeine has an excitatory action, the combination of these two substances balance the effects, producing a motility quite similar to that of control cells.”
The Influence of Non Polar and Polar Molecules in Mouse Motile Cells Membranes and Pure Lipid Bilayers“ Caffeine (10 mM) produced large transient currents that reversed close to the Cl(-) equilibrium potential and were blocked by 1 mM DIDS or 100 microM tetracaine.”
“Increase in Ca2+-signals with fluo 4 and rhod-2 caused by caffeine were reduced by tetracaine and oligomycin plus carbonyl cyanide m-chlorophenylhydrazone, respectively.”
“The release of ATP induced by caffeine (3 mM) was almost completely inhibited by ryanodine and tetracaine , but not by 2-APB, thus being mediated by ryanodine receptors (RyR).”
“The channel activator, caffeine , and the CRC inhibitor, tetracaine , are shown to interact competitively, which suggests that there exists a common site(s) on the CRC, that integrates the donor/acceptor effects of ligands.”
“ Caffeine at 0.5 mM in the presence of the same concentration of tetracaine failed to potentiate release flux independently of the test voltage applied.”
“Lower concentrations of tetracaine (0.5mm) and procaine (⩽10mm) blocked contractions due to caffeine (at pCa ⩾6.73), sulphydryl oxidizing agents, or Ca2+-induced Ca2+ release (CICR).”
“ Caffeine also antagonized the actions of tetracaine on the total available qgamma charge, but did so only at the low and not at the high applied concentrations.”
“ Tetracaine (10 microM to 2 mM) inhibited in a concentration‐dependent manner the Ca(2+)‐induced Ca2+ release (CICR) evoked by 5 mM caffeine.”
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