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Last Updated: 3 months ago

Possible Interaction: Caffeine and Tetracaine

supplement:

Caffeine

Research Papers that Mention the Interaction

The Ca2+-induced Ca2+ release blocker tetracaine inhibited the rise in [Ca2+]i induced by both caffeine and ATP, with apparent inhibitory constants of 70 μM and 100 μM, respectively.
Pflügers Archiv  •  2004  |  View Paper
In HBSM strips, caffeine induced a transient contraction which, likewise, was inhibited by ryanodine and tetracaine.
American journal of respiratory and critical care medicine  •  2000  |  View Paper
While tetracaine inhibits sperm motility and caffeine has an excitatory action, the combination of these two substances balance the effects, producing a motility quite similar to that of control cells.
PloS one  •  2013  |  View Paper
Caffeine (10 mM) produced large transient currents that reversed close to the Cl(-) equilibrium potential and were blocked by 1 mM DIDS or 100 microM tetracaine.
Investigative ophthalmology & visual science  •  2009  |  View Paper
Increase in Ca2+-signals with fluo 4 and rhod-2 caused by caffeine were reduced by tetracaine and oligomycin plus carbonyl cyanide m-chlorophenylhydrazone, respectively.
The release of ATP induced by caffeine (3 mM) was almost completely inhibited by ryanodine and tetracaine , but not by 2-APB, thus being mediated by ryanodine receptors (RyR).
Naunyn-Schmiedeberg's Archives of Pharmacology  •  2008  |  View Paper
The channel activator, caffeine , and the CRC inhibitor, tetracaine , are shown to interact competitively, which suggests that there exists a common site(s) on the CRC, that integrates the donor/acceptor effects of ligands.
Antioxidants & redox signaling  •  2007  |  View Paper
Caffeine at 0.5 mM in the presence of the same concentration of tetracaine failed to potentiate release flux independently of the test voltage applied.
Journal of Muscle Research & Cell Motility  •  2006  |  View Paper
Lower concentrations of tetracaine (0.5mm) and procaine (⩽10mm) blocked contractions due to caffeine (at pCa ⩾6.73), sulphydryl oxidizing agents, or Ca2+-induced Ca2+ release (CICR).
Journal of Muscle Research & Cell Motility  •  2005  |  View Paper
Caffeine also antagonized the actions of tetracaine on the total available qgamma charge, but did so only at the low and not at the high applied concentrations.
The Journal of physiology  •  1998  |  View Paper
Tetracaine (10 microM to 2 mM) inhibited in a concentration‐dependent manner the Ca(2+)‐induced Ca2+ release (CICR) evoked by 5 mM caffeine.
The Journal of physiology  •  1995  |  View Paper
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