Allen Institute for Artificial Intelligence logo

Discover Supplement-Drug Interactions

Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The tool is not a substitute for the care provided… (more)
Last Updated: a year ago

Possible Interaction: Caffeine and Tetrabenazine



Research Papers that Mention the Interaction

On the basis that TBZ augmented the secretory responses to caffeine (but not those of histamine), we monitored its effects on cytosolic Ca2+ elevations ([Ca2+]c) triggered by caffeine or histamine.
While the responses to caffeine were augmented twice by TBZ , those of histamine were unaffected; the same happened in rat cortical neurons.
The Journal of Pharmacology and Experimental Therapeutics  •  2019  |  View Paper
Caffeine at doses that had no effect on their own reversed the effects of TBZ on T‐maze performance, and also suppressed TBZ‐induced pDARPP‐32(Thr34) expression as measured by western blot, suggesting a role for D2‐A2A interactions.
Neuropharmacology  •  2018  |  View Paper