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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Caffeine
drug:
Temozolomide
Research Papers that Mention the Interaction
“Cell cycle analysis demonstrated that the proportion of cells arrested in G2 phase decreased when caffeine was administered together with TMZ ; at the same time, the amount of cells with micronucleation and multipolar spindle poles increased, indicative of enhanced mitotic cell death.”
“In conclusion, our study demonstrated that caffeine enhanced the efficacy of TMZ through mitotic cell death by impeding ATM/p53/p21-mediated G2 arrest.”
“Mechanistic study showed that coadministration of caffeine and TMZ suppressed the phosphorylation of ATM and p53 and downregulated p21 expression, thus releasing DNA-damaged cells from G2 arrest into premature mitosis.”
Caffeine Sensitizes U87-MG Human Glioblastoma Cells to Temozolomide through Mitotic Catastrophe by Impeding G2 Arrest“The AIF expressions of TMZ group and TMZ plus Caffeine group were higher significantly than that of the control group.”
“The LC-3A/B expression of TMZ plus Caffeine group was higher significantly than that of the control group and TMZ group.”
“The caspase-3 expression of TMZ plus Caffeine group was higher significantly than that of the control group and TMZ group.”
“The relative tumor fold of TMZ plus Caffeine group was lower significantly than that of TMZ group at day 14.”
Caffeine Inhibits Growth of Temozolomide-Treated Glioma via Increasing Autophagy and Apoptosis but Not via Modulating Hypoxia, Angiogenesis, or Endoplasmic Reticulum Stress in Rats.
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