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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
Research Papers that Mention the Interaction
“The clearance of a number of benzodiaze-pines undergoing oxidation (chlordiazepoxide, alprazolam, diazepam) and nitro reduction (nitrazepam), theophylline, prednisolone, caffeine and cyclosporin, is reduced in oral contraceptive steroid users.”
Pharmacokinetic Drug Interactions with Oral Contraceptives“An investigation has now been made into whether the changes in sex steroid levels that occur during normal menstrual cycling also affect the rate of caffeine elimination , especially whether hormonal shifts in the luteal phase are associated with slower elimination of caffeine.”
“ Caffeine or theophylline thus accelerated and/or intensified mammae lobulo-alveolar differentiation induced by the ovarian steroids.”
Caffeine, theophylline, theobromine, and developmental growth of the mouse mammary gland.“It is suggested that high steroid levels may in the long-term cause an altered hepatic clearance pattern affecting both steroid metabolism and caffeine elimination.”
“The administration of steroid hormones has been suggested to modulate the effects of caffeine , but unknown is whether endogenous hormone variations during the estrous cycle modulate the pharmacological effects of caffeine.”
Estrous cycle modulates the anxiogenic effects of caffeine in the elevated plus maze and light/dark box in female rats
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