Possible Interaction: Caffeine and Sodium Chloride

“Under calcium‐free solution, vessels from NaCl groups presented reduced contractile responses to phenylephrine and caffeine , compared with the regular chow group.”

“Addition of caffeine in the presence of low salt increased the affinity of Ca2+ activation by 1.7‐fold.”

“Bath application of 10 mM‐caffeine evoked a membrane current with a reversal potential close to ECl with either NaCl or sodium glutamate in the pipette.”

“Nevertheless, the presence of concentrated NaCl noticeably hindered CAF degradation.”

“This is due to the relatively stronger interactions of salt ions with caffeine at higher temperature.”

“Also observed are: (i) decrease in probability of salt contact ion pair as well as decrease in the solvent separated ion pair … with increasing salt concentration, (ii) a modest second shell collapse in the water structure, and (iii) dehydration of hydrophobic atomic sites of caffeine on addition of NaCl.”

“ Caffeine causes also a decrease in the sodium chloride content of the blood.”

“The factors which cause the sodium chloride to leave the body fluids are probably primarily responsible for the diuresis which takes place after administration of caffeine.”

“V. In normal animals, in nephrectomized animals and in animals in … operation not directly affecting the kidneys had been performed, caffeine causes an absolute and … in the elimination of sodium chloride from the peritoneal fluid, as a result of which … peritoneal fluid shows a lessened content of sodium chloride.”

“We see, therefore, that under the influence of caffeine a greater amount of sodium chloride is eliminated from the body fluids into the tissues or through the kidneys.”