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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Caffeine
drug:
Salicylic Acid
Research Papers that Mention the Interaction
“It was found that caffeine significantly increased the rate of appearance as well as the maximum concentration of salicylate in the plasma by about 25% and 17%, respectively.”
Influence of caffeine on aspirin pharmacokinetics“It was found that caffeine significantly increased the rate of appearance as well as the maximum concentration of the salicylate in plasma by about 31 and 15 per cent, respectively.”
“Addition of as little as 0.1 mM caffeine significantly enhances the toxicity of acetaminophen plus salicylic acid.”
Toxicity of Acetaminophen, Salicylic Acid, and Caffeine for First-Passage Rat Renal Inner Medullary Collecting Duct Cells“Pretreatment with salicylate (5 mM) reduced the twitch potentiation by quinine, shortened the duration of twitches in caffeine-treated muscles and inhibited the caffeine- and the quinine-induced contractures.”
“Acetaminophen and caffeine both retarded the appearance of salicylate in plasma.”
“This fact may be correlated with the different affinity between salicylate ion and caffeine as compared with that of undissociated salicylic acid.”
“In one such system, caffeine-salicylic acid, the salicylic acid actually decreased the absorption of caffeine due to an effect of the former on the gastric mucosa.”
“Complexation of part of the salicylic acid with caffeine resulted in a significant decrease in the over-all salicylic acid absorption rate under both conditions.”
“It appears, therefore, that the decreased absorption rate of salicylic acid in the presence of caffeine is due to the decreased thermodynamic activity of salicylic acid resulting from complex formation, with the complex being either unabsorbed or more slowly absorbed than free salicylic acid.”
“ Caffeine , theophylline, and theobromine react with sodium salicylate probably by means of hydrogen bonding to form an associated product.”
The action of solubilizing agents on the solubility of xanthine derivatives in water. III. The application of cryoscopy to the study of caffeine, theophylline, and theobromine with solubilizing agents.
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