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“Because salicylates have been reported to augment the stimulatory effects of caffeine on the CNS, attention was focused on the possibility that the presence of acetaminophen (52 micrograms/mL) reduced the CNS toxicity of caffeine.”
Journal of toxicology. Clinical toxicology • 1982 | View Paper
“It is suggested that endogenous caffeine stimulated production and/or deposition of salicylates , which possibly activated a series of defense reactions even under non-stressed conditions.”