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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
Research Papers that Mention the Interaction
“During the hedonic evaluation of saccharin, caffeine consumers had significantly greater activation in areas associated with memory and information processing.”
Taste Perception and Caffeine Consumption: An fMRI Study“Oral and IV caffeine robustly increased responding for saccharin in a manner that was repeatable, reliable, and systematically related to unit IV dose.”
Intravenous and oral caffeine self-administration in rats.“Acute PO caffeine also reduced saccharin intake.”
“Consumption … saccharin solution was significantly reduced in both isolated and enriched rats following administration of d-amphetamine (2 …/kg), cocaine (30 mg/kg), morphine (10 mg/kg), nicotine (1.0 mg/kg), caffeine (20 mg/kg), alcohol (1.5 g/kg), and LiCl (0.15 M, 4 ml/kg).”
“When nicotine 0.3 and 1 mg/….5, 1 and 2 mg/kg, and caffeine 30 mg/kg were administered … after intake of the saccharin solution , they exhibited a significant decrease in the preference for saccharin solution on … (namely conditioned aversion), even though no drug administration was carried out.”
“In Experiment 1B, caffeine was delivered 30 min before, 5 min before, or 30 min after saccharin.”
“ Saccharin forms water-soluble complexes with caffeine , various amides, and phenols.”
Complexing tendecies of saccharin in aqueous solutions.
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