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Discover Supplement-Drug Interactions
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Last Updated: 4 years ago
supplement:
Caffeine
drug:
Regadenoson
Research Papers that Mention the Interaction
“Caffeine is a competitive antagonist of all adenosine receptor subtypes; thus, caffeine is typically withheld 12–24 h before stress with regadenoson.”
Daily Caffeine Consumption Is Associated with Decreased Incidence of Symptoms and Hemodynamic Changes During Pharmacologic Stress with Regadenoson“These results suggest that caffeine exposure within 24 hours may reduce the effects of regadenoson administered for vasodilatory cardiac stress testing.”
“ Caffeine at 1, 2, 4, and 10 mg/kg significantly decreased the duration of the 2-fold increase in CBF induced by regadenoson by 17% ± 4%, 48% ± 8%, 62% ± 5%, and 82% ± 5%, respectively (all P < 0.05).”
“ Caffeine at 4 and 10 mg/kg significantly attenuated the effects of regadenoson on MAP and HR.”
“The results indicate that 1 to 10 mg/kg caffeine dose-dependently reduced the duration, but not the peak increase of CBF caused by 5 μg/kg regadenoson.”
Caffeine Attenuates the Duration of Coronary Vasodilation and Changes in Hemodynamics Induced by Regadenoson (CVT-3146), a Novel Adenosine A2A Receptor Agonist
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