Possible Interaction: Caffeine and Rabbit Allergenic Extract

“ Caffeine reversibly eliminated both the spontaneous and drug-induced action potentials of rabbit mesenteric veins without abolishing the resting membrane potential.”

“Here we show that under physiological conditions, application of low concentrations of caffeine (2-4 mM) to isolated single rabbit sinoatrial node cells acutely reduces their spontaneous action potential cycle length (CL) and increases Ca(2+) transient amplitude for several cycles.”

“In field stimulated (1 Hz) rabbit ventricular myocytes, application of 250 μm caffeine caused an initial 33% increase in SR Ca2+ release, which was followed by a decrease in SR Ca2+ load (28%) and steady‐state SR Ca2+ release (23%).”

“ Caffeine in concentration 12.5 mM, which did not displace Ca2 from guinea pig ventricular muscle, decreased Ca2 in the rabbit ventricle by 44%.”

“Third, rabbit RyR displayed less enhancement of [3H]ryanodine binding by caffeine in spite of having a similar magnitude of Ca2+ sensitization than the frog, which may explain the occasional difficulty by researchers to demonstrate caffeine contracture with mammalian skeletal muscles.”

“In contrast, caffeine contractures (where SR Ca2+ accumulation is inhibited), relaxed faster in rabbit cells.”

“ Caffeine (1-60 mM) induced concentration-dependent, endothelium-independent phasic contractile responses in isolated rabbit renal artery ring preparations.”

“The results of these studies indicate that the elimination of caffeine is diminished in late gestation in the rabbit.”

“ Caffeine (10 mM), theophylline (8 mM), dipyridamole (0.2 mM), or papaverine (0,05 mM) prevented the shape change of washed rabbit platelets induced by 0.4 microM ADP.”

“ Caffeine (10mM) increased developed force more in the rabbit than in the cat, while even 1 mM caffeine decreased force in the rat.”