Possible Interaction: Caffeine and Pyridostigmine Bromide

“Representative isobolograms plotted for each drug interaction illustrate that a beta-adrenoceptor agonist (isoproterenol), selective beta 2-adrenoceptor agonists (salbutamol, terbutaline), alpha 1- and alpha 2-adrenoceptor antagonists (yohimbine, phentolamine, prazosin), as well as the stimulant caffeine , strongly potentiate the lethal effect of PB.”

“These data demonstrate a toxic synergism between PB , several commonly used classes of adrenergic agents and caffeine when exposure occurs in different combinations.”