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Last Updated: 19 days ago

Possible Interaction: Caffeine and Pyrazinamide

supplement:

Caffeine

Research Papers that Mention the Interaction

This study investigated if, and in what manner, concomitant administration of caffeine affects PZA metabolism.
kg−1 caffeine … PZA increased from the excretion (p<0.05) of the most water‐soluble and the least toxic PZA metabolite 5‐hydroxypyrazinoic acid (5‐OH‐… 173.23±17.82 μmol/24 h. These results show that the metabolic disposition of PZA is affected by concomitant caffeine intake.
Biopharmaceutics & drug disposition  •  2002  |  View Paper