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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Caffeine
drug:
Propafenone
Research Papers that Mention the Interaction
“Increasing RyR2 activity of permeabilized WT myocytes by exposure to caffeine (150 µM) increased the potency of FLEC and RPROP but not of TET.”
Channel Activity of Cardiac Ryanodine Receptors (RyR2) Determines Potency and Efficacy of Flecainide and R-Propafenone against Arrhythmogenic Calcium Waves in Ventricular Cardiomyocytes“ Caffeine has intrinsic proarrhythmic effects; thus, its coadministration with an antiarrhythmic agent such as propafenone should be used with caution, especially in patients with poor CYP2D6 activity.”
“Concomitant administration of propafenone decreased caffeine oral clearance from 8.3 ± 0.9 L/h to 5.4 ± 0.7 L/h (P < 0.05).”
“Concomitant administration of propafenone to this volunteer caused the greatest increase in caffeine plasma concentrations.”
“Elimination half-life of caffeine was also increased 54% by propafenone.”
“Our results suggest that propafenone causes significant inhibition of CYP1A2 activity leading to a decrease in the clearance of caffeine.”
“These results support the concept of competitive inhibition between propafenone and caffeine.”
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