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Last Updated: 3 months ago

Possible Interaction: Caffeine and Propafenone

supplement:

Caffeine

Research Papers that Mention the Interaction

Caffeine has intrinsic proarrhythmic effects; thus, its coadministration with an antiarrhythmic agent such as propafenone should be used with caution, especially in patients with poor CYP2D6 activity.
Concomitant administration of propafenone decreased caffeine oral clearance from 8.3 +/- 0.9 L/h to 5.4 +/-
Concomitant administration of propafenone decreased caffeine oral clearance from 8.3 +/- 0.9 L/h to 5.4 +/- 0.7 L/h (P < 0.05).
Concomitant administration of propafenone to this volunteer caused the greatest increase in caffeine plasma concentrations.
Elimination half-life of caffeine was also increased 54% by propafenone.
Our results suggest that propafenone causes significant inhibition of CYP1A2 activity leading to a decrease in the clearance of caffeine.
These results support the concept of competitive inhibition between propafenone and caffeine.
Therapeutic drug monitoring  •  2006  |  View Paper
Increasing RyR2 activity of permeabilized WT myocytes by exposure to caffeine (150 µM) increased the potency of FLEC and RPROP but not of TET.
PloS one  •  2015  |  View Paper
Propafenone depressed the amplitude and Vmax and shortened the duration of the slow action potentials induced by isoprenaline and caffeine in K-depolarized papillary muscles.
British journal of pharmacology  •  1985  |  View Paper