Possible Interaction: Caffeine and Potassium

“ Caffeine ingestion increased sweat losses of sodium, chloride, and potassium ( approximately 14%; P < 0.05) and enlarged urine flow (28%; P < 0.05).”

“Total urine output of water, calcium, magnesium, sodium, chloride, potassium and creatinine increased in the two hours following caffeine ingestion when compared to the control beverage.”

“ Caffeine , a prototypic bitter stimulus, produces several physiological actions on taste receptor cells that include inhibition of KIR and KV potassium currents and elevations of intracellular calcium.”

“At behaviorally relevant concentrations, caffeine produced strong inhibition of outwardly and inwardly rectifying potassium currents.”

“These results suggest that caffeine induces a decrease in membrane potassium conductance of the OHCs mainly at the basal region without mediating the intracellular signaling pathway.”

“Fibres which, whilst intact, were stimulated repeatedly by potassium depolarization with simultaneous application of 30 mM caffeine showed reduced responsiveness after skinning to depolarization but not to caffeine.”

“ Caffeine caused a negative balance of potassium , sodium and inorganic phosphate.”

“Treatment … mM caffeine under condition of repetitive stimulation … of the phasic component of potassium contraction (100 mM KCl), as well as prevents the phasic component suppression due to 15-min application of … X 10(-5) g/ml) or to a long-lasting (15-20 min) inactivity of the preparation.”

“3 Low levels of depolarization by potassium (10–40 mm) augmented the amplitude of the caffeine contracture , while higher concentrations of potassium depressed the contracture.”

“Maximum augmentation of the caffeine contracture occurred with a higher concentration of potassium (20 mm vs 10 mm) in the e.d.l.”

“Both proctolin (10−8 M) and caffeine (10−3 M) induced substantial contractures of the hindgut after depolarization in 158 mM potassium.”