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Last Updated: 3 years ago

Possible Interaction: Caffeine and Pirfenidone

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supplement:

Caffeine

drug:

Pirfenidone

Research Papers that Mention the Interaction

“Various studies highlighted the ability of targeting CAF with pirfenidone (PFD), leading to increased efficacy of chemotherapy.”

Pirfenidone reduces immune-suppressive capacity of cancer-associated fibroblasts through targeting CCL17 and TNF-beta.

Integrative biology : quantitative biosciences from nano to macro • 2020 | View Paper

“Interestingly, although the expression of the Na+/Ca2+ exchanger (NCX) was unaffected, the decay of Ca2+ signal in the presence of caffeine was 50% slower in PFD-treated cells (compared with controls), suggesting that PFD downregulates the activity of the exchanger.”

Long-Term Regulation of Excitation–Contraction Coupling and Oxidative Stress in Cardiac Myocytes by Pirfenidone

Front. Physiol. • 2018 | View Paper

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