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Discover Supplement-Drug Interactions

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Last Updated: 2 years ago

Possible Interaction: Caffeine and Pirfenidone

supplement:

Caffeine

Research Papers that Mention the Interaction

Various studies highlighted the ability of targeting CAF with pirfenidone (PFD), leading to increased efficacy of chemotherapy.
Integrative biology : quantitative biosciences from nano to macro  •  2020  |  View Paper
Interestingly, although the expression of the Na+/Ca2+ exchanger (NCX) was unaffected, the decay of Ca2+ signal in the presence of caffeine was 50% slower in PFD-treated cells (compared with controls), suggesting that PFD downregulates the activity of the exchanger.
Front. Physiol.  •  2018  |  View Paper