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Last Updated: 4 months ago

Possible Interaction: Caffeine and Pirarubicin

supplement:

Caffeine

Research Papers that Mention the Interaction

In the presence of caffeine, THP inhibited catalepsy intensity with an ED(50) of 0.19 mg/kg, and prolonged the latency with an ED(50) of 0.30 mg/kg.
In these animals, caffeine was still able to enhance the anticataleptic actions of THP , suggesting that repeated administration of 1 mg/kg caffeine does not induce tolerance to the synergism with anticholinergics.
The synergism was more evident when THP was administered at subthreshold doses that were unable to modify haloperidol-induced catalepsy when applied alone, but produced a clear inhibition of catalepsy when injected with caffeine.
To assess whether repeated administration of caffeine could induce tolerance to the synergism with THP , a group of rats was pretreated with three daily doses of caffeine (1 mg/kg) for seven days, and the catalepsy test was performed on the eighth day.
Neuropharmacology  •  2003  |  View Paper