“It was also shown that piperine can potentiate the effect of a low dose of caffeine and can reverse the effect of diazepam.”
“ Piperine improved the effect of a low dose of caffeine (25 mg/kg intraperitoneally after a shock of 2 s duration) in a first assessment (295.17 s vs 149.17 s, P = 0.026) compared to a higher dose of caffeine.”