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Discover Supplement-Drug Interactions
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Last Updated: 2 years ago
supplement:
Caffeine
drug:
Pioglitazone
Research Papers that Mention the Interaction
“CONCLUSION Co-administration of PI wi th caf feine en hances its antidiabetic effect, probably due to enhanced bioavailability of PIO, leading to clinical benefits in diabetic patients.”
“Combination of PIO and caffeine produced a synergistic effect on percentage reduction in blood glucose, with 67.1% reductions observed on day 7 and 68.9% reductions observed on day 14.”
“Conclusion: Co-administration of PIO with caffeine enhances its antidiabetic effect, probably due to enhanced bioavailability of PIO, leading to clinical benefits in diabetic patients.”
“Results: Caffeine caused statistically marked increases in area under the curve, Cmax, Tmax, and half-life of PIO , and decreased clearance.”
Caffeine modulates pharmacokinetic and pharmacodynamic profiles of pioglitazone in diabetic rats
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