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Last Updated: 2 years ago

Possible Interaction: Caffeine and Phenytoin

supplement:

Caffeine

Research Papers that Mention the Interaction

Interestingly, animal data have demonstrated that caffeine , at doses far below its convulsive potential, diminishes the protective effects of conventional antiepileptic drugs (AEDs--carbamazepine, phenobarbital, phenytoin , valproate) and the newer AED, topiramate against electroconvulsions in mice.
Pharmacological reports : PR  •  2011  |  View Paper
Acute caffeine , in doses far below its convulsive potential (almost 10-20 fold lower than the ED50 of the methylxanthine of ….03 mmol/kg for the induction of seizures), produced a significant reduction in the anticonvulsant effects of carbamazepine, phenobarbital, phenytoin , and valproate against maximal …-induced seizures in mice.
Przeglad lekarski  •  2007  |  View Paper
On the other hand, phenytoin alone increased the clearance of caffeine from 1.5 (controls) to 3.6 ml · min−1 · kg−1, and reduced its half life from 4.8 to 2.4 h. Carbamazepine and valproic acid had no effect on caffeine metabolism.
European Journal of Clinical Pharmacology  •  2004  |  View Paper
Caffeine has been reported to be proconvulsant and to reduce the anticonvulsant efficacy of a variety of antiepileptic drugs (carbamazepine, phenobarbital, phenytoin , valproate and topiramate) in animal models of epilepsy and to increase seizure frequency in patients with epilepsy.
Pharmacological reports : PR  •  2009  |  View Paper
A strong impairment of the anticon-vulsant action of CBZ and DPH was observed when a challenge dose of CAFF was injected following either 24 or 72 h injection-free time.
Moreover the ED50 values for both, CBZ and DPH , evaluated 24 h after a 14-day treatment with CAFF (in doses of 23.1 and 46.2 mg/kg, respectively), were significantly elevated compared to respective control groups.
Pharmacology Biochemistry and Behavior  •  1996  |  View Paper
Interaction with CAF (200 mg/kg, ip) abolished the seizure protection by DPH and DZP, reduced that by PB to 20%, while the protective effect of SV was unchanged.
Indian journal of experimental biology  •  1991  |  View Paper
The depressant actions of both adenosine and diphenylhydantoin were antagonized by caffeine (20 mg/ kg).
Epilepsia  •  1984  |  View Paper