Allen Institute for Artificial Intelligence
supp.ai logo
supp.ai

Discover Supplement-Drug Interactions

Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The tool is not a substitute for the care provided… (more)
Last Updated: 2 years ago

Possible Interaction: Caffeine and Phenylephrine

supplement:

Caffeine

Research Papers that Mention the Interaction

Prenatal exposure to caffeine increased pressor responses and vasoconstrictions to phenylephrine , accompanied by enhanced membrane depolarization.
Scientific reports  •  2015  |  View Paper
10 mM caffeine (CAF) increased of [Ca2+]i in NPE and PE (NPE > PE) and sometimes produced very slow oscillations with an interval of 10 to 25 s. Prior administration of CAF strongly suppressed the effects of ACH, CARB, EPI, PHE , histamine, and adenosine 5-triphosphate (ATP).
Current eye research  •  1997  |  View Paper
Kinetic analysis of these data indicated that caffeine reduced the Ca2+ content of the same intracellular compartment depleted by phenylephrine , whereas forskolin depleted a different intracellular Ca2+ store.
The American journal of physiology  •  1989  |  View Paper
Since caffeine is known to inhibit phosphodiesterase, the additional stimulation of both syntheses by caffeine plus phenylephrine may be due to the synergistic effect of increases in cAMP and [Ca2+].
The Japanese journal of physiology  •  1987  |  View Paper
On the other hand, Takagi, Takayanagi and Tomiyama (4, 5) have reported that the relaxing effects of papaverine and isoprenaline, a beta-adrenergic stimulant, … that caffeine and imidazole, which influence phosphodiesterase activity, considerably modify the responses of the taenia to isoprenaline and papaverine, while the action of phenylephrine, … caffeine ….
Japanese journal of pharmacology  •  1972  |  View Paper