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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Caffeine
drug:
Phentolamine
Research Papers that Mention the Interaction
“ Phentolamine (5 mg/kg) enhanced antinociception by caffeine in both the HP and formalin tests, but inhibited locomotor stimulation.”
Caffeine antinociception in the rat hot-plate and formalin tests and locomotor stimulation: involvement of noradrenergic mechanisms“ Caffeine (5 mM)-induced contraction in the presence of verapamil and phentolamine was significantly smaller in SHR than in WKY.”
“The blockade by phentolamine could be surmounted by increasing the dose of caffeine , the partial blockade by diazepam and 2-chloroadenosine could not.”
“The discriminative effects of … mg/kg of caffeine were blocked dose-dependently and completely … alpha adrenergic receptor blocking drugs ( phentolamine , prazosin and yohimbine) and were blocked partially by propranolol and by drugs having behavioral depressant … (diazepam, pentobarbital and the adenosine analogs, R-(-)-N6-(2-phenylisopropyl)adenosine, cyclohexyladenosine, 2-chloroadenosine).”
“However, synergism between norepinephrine and caffeine did occur in the presence of phentolamine.”
“In the presence of caffeine, phentolamine concentrations as low as 5 · 10−7 M significantly enhanced cyclic AMP accumulation stimulated by 3 · 10−5 M epinephrine or norepinephrine.”
“The α-adrenergic antagonists phenoxybenzamine and phentolamine enhanced norepinephrine-stimulated cyclic AMP accumulation in the presence of caffeine.”
“These observations suggest a cooperative effect of phentolamine and caffeine on enhancing the intracellular accumulation of cyclic AMP.”
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