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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Caffeine
drug:
Pentoxifylline
Research Papers that Mention the Interaction
“The picture now emerging shows that Caffeine and Pentoxifylline inhibit homologous recombination by targeting members of the PIK kinase family (ATM and ATR) which facilitate repair in G2.”
Inhibition of DNA repair by Pentoxifylline and related methylxanthine derivatives.“ Methylxanthine drugs pentoxifylline (OR, 0.72; 95% CI, 0.59-0.89) and theophylline (OR, 0.77; 95% CI, 0.66-0.91), and the corticosteroid dexamethasone (OR, 0.72; 95% CI, 0.61-0.85) were associated with decreased odds of PD.”
“Several studies have shown that pentoxifylline potently suppresses production of IL-12 in a concentration-dependent manner [3] and this methylxanthine derivative might have a role in immunological disorders characterised by inappropriate type-1 immune responses [4].”
“However, caffeine stimulated and pentoxifylline inhibited PMN oxidative activity.”
“The results clearly showed that caffeine and pentoxifylline were competitive inhibitors of ATP in the enzymatic phosphorylation.”
“For this effect pentoxifylline was about 10 times more potent than caffeine.”
Effects of the methylxanthine derivative pentoxifylline on benzodiazepine and muscarinic binding sites in rat cerebral cortex.“Given considerable exposure to caffeine and pentoxifylline , these interactions might be relevant for the effectiveness of antibacterial pharmacotherapy, and may help to identify optimal treatment regimens in the era of multidrug resistance.”
Modulatory Effects of Caffeine and Pentoxifylline on Aromatic Antibiotics: A Role for Hetero-Complex Formation
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