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Last Updated: 2 years ago

Possible Interaction: Caffeine and Pentobarbital

supplement:

Caffeine

Research Papers that Mention the Interaction

Caffeine (10 mg/kg) ameliorated the decreased response rate and the % of avoidance produced by diazepam and pentobarbital.
Japanese journal of pharmacology  •  1992  |  View Paper
Although diazepam (0.25, 0.5 and 2 mg/kg s. c.) and pentobarbital (1, 3 and 10 mg/kg s. c.) alone did not change the activity, they significantly reduced the effect of caffeine.
Arukoru kenkyu to yakubutsu izon = Japanese journal of alcohol studies & drug dependence  •  1992  |  View Paper
Caffeine combined with pentobarbital also yielded an inconsistent decrease in drug lever responding in baboons but there was no effect in rats.
European journal of pharmacology  •  1985  |  View Paper
When combined with the caffeine training dose, pentobarbital also produced a dose-dependent decrease in response rate but not in drug lever choices.
Pharmacology Biochemistry and Behavior  •  1985  |  View Paper
Competitive antagonism was found for the interaction between caffeine and ethanol, caffeine and pentobarbital, strychnine and atropine and strychnine and pentobarbital.
Pharmacology  •  1983  |  View Paper
Caffeine and pentobarbitone in combination were not more effective than caffeine alone in this respect.
However, when 16 mg/kg pentobarbitone was given after caffeine , the effects appeared to be more than additive.
Acta pharmacologica et toxicologica  •  1975  |  View Paper
Caffeine (l0−2M)-induced contraction was significantly attenuated by thiamylal at concentrations greater than 10−4M and by pentobarbital at 3×10−4M.
Journal of Anesthesia  •  1991  |  View Paper