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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Caffeine
drug:
Pefloxacin
Research Papers that Mention the Interaction
“Addition of the quinolone antibiotic agents pipemidic acid or pefloxacin , both known to inhibit caffeine metabolism in vivo and in human liver microsomes, reduced formation rates of all metabolites of caffeine in cells expressing rat and human P450IA2.”
Biotransformation of methylxanthines in mammalian cell lines genetically engineered for expression of single cytochrome P450 isoforms. Allocation of metabolic pathways to isoforms and inhibitory effects of quinolones.“Fluoroquinolones, especially enoxacin, and to a lesser extent ciprofloxacin and pefloxacin , inhibit the metabolic clearance of theophylline and caffeine.”
“Oxo-metabolites of enoxacin and, to a lesser extent, pefloxacin and ciprofloxacin interfere with the hepatic elimination of theophylline and caffeine and may result in toxicity due to these agents if dosage is not modified.”
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