Allen Institute for Artificial Intelligence
supp.ai logo
supp.ai

Discover Supplement-Drug Interactions

Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The tool is not a substitute for the care provided… (more)
Last Updated: 2 years ago

Possible Interaction: Caffeine and Paclitaxel

supplement:

Caffeine

Research Papers that Mention the Interaction

Furthermore, caffeine decreased the inhibitory effect of paclitaxel on tumor growth through down-regulation of α-tubulin acetylation in vivo.
Here, we investigated whether caffeine inhibits the antitumor activity of paclitaxel via down-regulation of α-tubulin acetylation.
Studies have shown that caffeine reduces the cytotoxic effects of paclitaxel and inhibits paclitaxel-induced apoptosis; however, the underlying mechanism remains unclear.
Taken together, these findings demonstrate that caffeine inhibits the anticancer activity of paclitaxel via down-regulation of α-tubulin acetylation, suggesting that patients receiving treatment with taxanes, such as paclitaxel, should avoid consuming caffeinated beverages or foods.
The results showed that caffeine promoted the growth of cancer cells treated with paclitaxel.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie  •  2020  |  View Paper
Paclitaxel (PTX) and acriflavine (ACF) were identified as the most promising molecules to inhibit CAF development.
International journal of pharmaceutics  •  2020  |  View Paper
In conclusion, this study provides preliminary evidence that caffeine , not chlorogenic acid, modulates the cytotoxicity of doxorubicin, gemcitabine, and paclitaxel in SH-SY5Y cells via different mechanisms.
Toxicology mechanisms and methods  •  2017  |  View Paper
In conclusion, coadministration of cell cycle‑modifying agents, including caffeine should be avoided in CRC patients treated with paclitaxel.
Moreover, administration of caffeine may decrease chemotherapeutic responses to paclitaxel by the MEK‑ERK mediated upregulation of Mcl‑1.
Molecular medicine reports  •  2014  |  View Paper
We found that paclitaxel combined with caffeine or UCN-01, inhibitors of G(2) DNA damage checkpoint, was able to partially overcome resistance to paclitaxel in these cells.
American journal of physiology. Gastrointestinal and liver physiology  •  2012  |  View Paper
As for the effect of caffeine on paclitaxel, caffeine suppressed the effect of paclitaxel on cell cycle distribution, where a dose-dependent early increase in G2-M and a decrease in G1 were not clear.
Caffeine combined with paclitaxel clearly suppressed cell proliferation in a dose-dependent manner.
The cell killing effect, due to paclitaxel, increased in a dose-dependent manner up to 50 nM. For combined treatment with caffeine and paclitaxel , added caffeine reduced the cytotoxic effect of paclitaxel not only in dose-response but also in time-response curves.
This study was performed to investigate how caffeine modifies the cytotoxic effects of paclitaxel on a human lung carcinoma cell line.
We suggest that cell cycle modifying agents, such as caffeine , potentially diminish the cytotoxic activity of paclitaxel , and one should be careful when combining such agents.
Cancer letters  •  2003  |  View Paper