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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Caffeine
drug:
Oxcarbazepine
Research Papers that Mention the Interaction
“Low doses of caffeine given systemically inhibit antinociception by several analgesics (acetaminophen, amitriptyline, oxcarbazepine , cizolirtine), probably reflecting block of a component of action involving adenosine A(1) receptors.”
Methylxanthines and pain.“ Caffeine (1000-1500 nmol/paw), a nonselective adenosine receptor antagonist, as well as 1,3-dipropyl-8-cyclopentylxanthine (DPCPX) (10-30 nmol/paw), a selective A1 receptor antagonist, coadministered with OXC , significantly depressed its anti-hyperalgesic effect.”
Peripheral anti-hyperalgesia by oxcarbazepine: involvement of adenosine A1 receptors.
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