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Discover Supplement-Drug Interactions
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Last Updated: 2 years ago
supplement:
Caffeine
drug:
Norfloxacin
Research Papers that Mention the Interaction
“There was a decline in caffeine metabolite levels in the 24‐hour urine samples for both quinolone treatments, suggesting that pipemidic acid and, to a lesser degree, norfloxacin inhibit metabolism of the N‐demethylation pathways of caffeine.”
Effect of quinolones on caffeine disposition“The results show that the catabolism of caffeine is inhibited by ~65% after five days of NFX administration, consequently the caffeine concentration in the urine sample is increased, which is reflected in terms of ~2.5 times increase in the peak current of caffeine.”
“Some of the fluoroquinolones norfloxacin , ciprofloxacin, and ofloxacin) can inhibit the cytochrome P-450 enzyme system and thereby cause increased serum concentrations of drugs like theophylline and caffeine.”
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