Possible Interaction: Caffeine and Norepinephrine

“Overall, the results suggest that caffeine counteracts reductions in the turnover of central noradrenaline.”

“At exhaustion in the 2- and 4-day withdrawal trials, there were significant increases in plasma norepinephrine in response to caffeine ingestion.”

“Postprandial plasma noradrenaline levels were higher (P < 0.02) and the increase greater (P < 0.02) after caffeine than after placebo.”

“Single ingestion of caffeine accelerated the elimination of E and NE and increased the maximal blood lactic acid.”

“Plasma insulin and norepinephrine were lower after caffeine ingestion, whereas an increase in plasma free fatty acids was noted.”

“ Caffeine increased plasma renin activity by 57 per cent, plasma norepinephrine by 75 per cent and plasma epinephrine by 207 per cent.”

“ Caffeine activates noradrenaline neurons and seems to affect the local release of dopamine.”

“Experiments on rabbits have shown that caffeine (10 mg/kg), ethimizol (10 mg/kg) and particularly bemegride (5 mg/kg) increase the blood adrenaline and noradrenaline content up to the level characteristic for intact animals under acute ethanol poisoning (2.5 g/kg per os).”

“EDs include high amounts of caffeine (32 mg/100 ml, although some 250 ml drinks contain 80 mg, while 500 ml … on the nervous system exactly like psychoactive substances, producing dependency particularly in students who use these drinks for exams because caffeine … noradrenaline and dopamine in … concentration for studying.”

“ Norepinephrine concentration was significantly greater in CAFF (290.6 ± 113.0 pg/mL, 278.1 ± 91.4 pg/mL, and 399.8 ± 125.5 pg/mL) than NCAFF (105.6 ± 29.5 pg/mL, 199.6 ± 89.6 pg/mL, and 361.5 ± 171.3 pg/mL).”