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Possible Interaction: Caffeine and Nitric Oxide

supplement:

Caffeine

Research Papers that Mention the Interaction

It was therefore hypothesised that caffeine may alter exhaled NO (eNO) levels.
It was therefore hypothesised that caffeine may alter exhaled NO (eNO) levels.
Thorax  •  2002  |  View Paper
Several studies demonstrate that caffeine causes vasodilation via the nitric oxide pathway.
Annals of plastic surgery  •  2015  |  View Paper
RESULTS Conditioned medium of MSCs treated with caffeine significantly enhanced phagocytosis and simultaneously regressed expression of reactive oxygen species (ROS) and nitric oxide (NO) as well as IL-12 by macrophages compared to the supernatants of MSCs alone.
RESULTS Conditioned medium of MSCs treated with caffeine significantly enhanced phagocytosis and simultaneously regressed expression of reactive oxygen species (ROS) and nitric oxide (NO) as well as IL-12 by macrophages compared to the supernatants of MSCs alone.
Cell journal  •  2017  |  View Paper
Administration of nicotine or caffeine caused a significant (P<0.05) inhibition on AChE, ADA and Arg activities as well as a significant increase in NO level when compared with the control.
Pathophysiology : the official journal of the International Society for Pathophysiology  •  2016  |  View Paper
An ATR-kinase dead mutant or caffeine , which blocks the kinase activity of ATR, effectively abolishes the ability of NO to cause p53 nuclear retention, concomitant with its inhibition of p53 serine 15 phosphorylation.
Cell Death and Differentiation  •  2003  |  View Paper
In this regard, nitric oxide NO ) is partly involved in the central effects of caffeine.
Moreover, NOx levels significantly decreased following alone administration of caffeine (100 mg/kg) or 8-CPT (5 mg/kg).
Epilepsy Research  •  2019  |  View Paper
The increased malondialdehyde, lucigenin and NO levels with acute stress were inhibited with chronic caffeine (p<0.05-0.01), malondialdehyde and NO levels were declined by acute caffeine (p<0.001).
Physiology & Behavior  •  2017  |  View Paper
Caffeine decreased the LPS-induced inflammatory mediator, nitric oxide ( NO).
Chemico-biological interactions  •  2016  |  View Paper
Moreover, caffeine protection against alcohol increased nitric oxide (NO•) levels over those found in the presence of ethanol alone, disappeared upon blocking NO• synthase, and could not be detected in pressurized cerebral arteries from endothelial nitric-oxide synthase knockout (eNOS(-/-)) mice.
The Journal of pharmacology and experimental therapeutics  •  2015  |  View Paper
Caffeine substantially suppressed the LPS-induced pro-inflammatory mediators nitric oxide (NO), prostaglandin E(2) (PGE(2)) and tumor necrosis factor-α (TNF-α) in BV2 microglial cells.
Taken together, our data indicate that caffeine suppresses the generation of pro-inflammatory mediators, such as NO , PGE(2) and TNF-α as well as their regulatory genes in LPS-stimulated BV2 microglial cells by inhibiting Akt-dependent NF-κB activation and the ERK signaling pathway.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association  •  2012  |  View Paper
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