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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Caffeine
drug:
Nitric Oxide
Research Papers that Mention the Interaction
“Background: Caffeine is known to inhibit phosphodiesterases, to mobilise intracellular calcium, and to act as an antagonist at adenosine receptors, all of which can potentially alter nitric oxide ( NO ) production.”
Caffeine decreases exhaled nitric oxide“An ATR-kinase dead mutant or caffeine , which blocks the kinase activity of ATR, effectively abolishes the ability of NO to cause p53 nuclear retention, concomitant with its inhibition of p53 serine 15 phosphorylation.”
“Although the targets of NO have not yet been completely described, it is known that NO can bind to the iron contained in heine groups, leading to conformational changes in associated proteins, such as guanylyl cyclase.”
“Also, caffeine significantly increased (p < .05) activity of creatine kinase and insignificantly (p > .05) altered nitric oxide and free calcium levels in seminal plasma.”
“Also, caffeine significantly increased (p < .05) activity of creatine kinase and insignificantly (p > .05) altered nitric oxide and free calcium levels in seminal plasma.”
“We read with interest the paper by Bruce et al 1 which reported a significant decrease in exhaled nitric oxide NO ) levels 1 hour after caffeine consumption.”
“In this regard, nitric oxide NO ) is partly involved in the central effects of caffeine.”
“Moreover, NOx levels significantly decreased following alone administration of caffeine (100 mg/kg) or 8-CPT (5 mg/kg).”
Effect of acute caffeine administration on PTZ-induced seizure threshold in mice: Involvement of adenosine receptors and NO-cGMP signaling pathway“The increased malondialdehyde, lucigenin and NO levels with acute stress were inhibited with chronic caffeine (p<0.05-0.01), malondialdehyde and NO levels were declined by acute caffeine (p<0.001).”
“ Caffeine decreased the LPS-induced inflammatory mediator, nitric oxide ( NO).”
“In addition, caffeine inhibited LPS-induced NO production in zebrafish.”
“Moreover, caffeine protection against alcohol increased nitric oxide (NO•) levels over those found in the presence of ethanol alone, disappeared upon blocking NO• synthase, and could not be detected in pressurized cerebral arteries from endothelial nitric-oxide synthase knockout (eNOS−/−) mice.”
“Both Glut4 and NO seem to be downstream effectors involved in insulin resistance induced by acute caffeine.”
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