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Last Updated: 2 months ago

Possible Interaction: Caffeine and Nitric Oxide

supplement:

Caffeine

Research Papers that Mention the Interaction

Background: Caffeine is known to inhibit phosphodiesterases, to mobilise intracellular calcium, and to act as an antagonist at adenosine receptors, all of which can potentially alter nitric oxide ( NO ) production.
Thorax  •  2002  |  View Paper
An ATR-kinase dead mutant or caffeine , which blocks the kinase activity of ATR, effectively abolishes the ability of NO to cause p53 nuclear retention, concomitant with its inhibition of p53 serine 15 phosphorylation.
Cell Death and Differentiation  •  2003  |  View Paper
Although the targets of NO have not yet been completely described, it is known that NO can bind to the iron contained in heine groups, leading to conformational changes in associated proteins, such as guanylyl cyclase.
Annual review of neuroscience  •  1994  |  View Paper
We read with interest the paper by Bruce et al 1 which reported a significant decrease in exhaled nitric oxide NO ) levels 1 hour after caffeine consumption.
Thorax  •  2003  |  View Paper
In this regard, nitric oxide NO ) is partly involved in the central effects of caffeine.
Moreover, NOx levels significantly decreased following alone administration of caffeine (100 mg/kg) or 8-CPT (5 mg/kg).
Epilepsy Research  •  2019  |  View Paper
The increased malondialdehyde, lucigenin and NO levels with acute stress were inhibited with chronic caffeine (p<0.05-0.01), malondialdehyde and NO levels were declined by acute caffeine (p<0.001).
Physiology & Behavior  •  2017  |  View Paper
Caffeine decreased the LPS-induced inflammatory mediator, nitric oxide ( NO).
In addition, caffeine inhibited LPS-induced NO production in zebrafish.
Chemico-biological interactions  •  2016  |  View Paper
Moreover, caffeine protection against alcohol increased nitric oxide (NO•) levels over those found in the presence of ethanol alone, disappeared upon blocking NO• synthase, and could not be detected in pressurized cerebral arteries from endothelial nitric-oxide synthase knockout (eNOS−/−) mice.
The Journal of Pharmacology and Experimental Therapeutics  •  2016  |  View Paper
Both Glut4 and NO seem to be downstream effectors involved in insulin resistance induced by acute caffeine.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences  •  2015  |  View Paper
These results demonstrate that guaraná has an antioxidant effect on NO metabolism in situations with higher cellular NO levels.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association  •  2013  |  View Paper
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