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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Caffeine
drug:
Niflumic Acid
Research Papers that Mention the Interaction
“Upon application of the niflumic acid under K+-free conditions, most of the current induced by caffeine was inhibited.”
Ca2+-dependent membrane currents in vascular smooth muscle cells of the rabbit.“4 Caffeine (10 mm) induced currents that reversed at ECl and were blocked by niflumic acid (10 μm).”
“However, at a concentration of 100 microM, niflumic acid significantly inhibited IBK(Ca)) evoked by caffeine (10 mM) but not by NS1619 (1-(2'-hydroxy-5'-trifluoromethylphenyl)-5-trifluoromethyl-2(3 H) benzimidazolone; 20 microM).”
“In freshly dispersed portal vein cells clamped at -60 mV in caesium (Cs+)-containing solutions, niflumic acid (1-100 microM) inhibited calcium (Ca2+)-activated chloride currents (IC1(Ca)) induced by caffeine (10 mM) and by noradrenaline (10 microM).”
“The …/l NFA on the GABA-evoked inward current were also strongly inhibited by nitrendipine (NTDP; an L-type calcium …(2-aminophenoxy)ethane-N,N,N′,N′-tetraacetic acid tetrakis (a highly selective calcium chelating reagent), caffeine (a widely available Ca2+ consuming drug) … fluid, in a concentration-dependent manner.”
NSAIDs modulate GABA-activated currents via Ca2+-activated Cl− channels in rat dorsal root ganglion neurons
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