Possible Interaction: Caffeine and Niacin

“ Niacinamide and adenosine decreased the amount of chromosomal aberrations detected in FA homozygote and heterozygote lymphocytes treated and untreated with caffeine during G2 prophase.”

“ Caffeine pretreatment was also observed to eliminate nicotinic responses but not elevated extracellular K(+)-induced responses, suggesting that caffeine blocks nicotinic receptor-channels.”

“A combination of nicotinamide with orotic acid or with caffeine leads to substances with a higher effect on TAT induction.”

“The combined action of NA and caffeine showed a synergism.”

“ Caffeine (10 mM) prolonged the afterhyperpolarization of an action potential, reduced the amplitude of the ACh ( nicotinic ) potential and induced slow rhythmic hyperpolarizations in a 20 mM Ca2+ solution.”

“These results suggest that caffeine suppresses the nicotinic transmission of the bullfrog sympathetic ganglion by both the pre- and postsynaptic actions and that a considerable portion of the postsynaptic action was the result of a rise in the intracellular free Ca2+ concentration.”

“ Nicotinic acid alone did not affect the firing rate of reticular units, but antagonized the effects of caffeine.”

“ Nicotinic acid reduced the mortality of rats given 300 mg kg of caffeine and delayed the time of death of those animals that did succumb.”

“The effects of amino phylline and caffeine , both during indirect and direct stimulation, were equally depressed or abolished by nicotinic acid.”

“When caffeinesodium bensoate plus nicotinic acid was given concomitantly, the FFA-lowering effect of nicotinic acid prevailed.”

“This effect was enhanced by simultaneous administration of the antilipolytic agent nicotinic acid and completely reversed by pretreatment of the animals with caffeine (which stimulates lipolysis).”