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Discover Supplement-Drug Interactions

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Last Updated: a year ago

Possible Interaction: Caffeine and Nefazodone

supplement:

Caffeine

Research Papers that Mention the Interaction

Our previous studies showed that some of the tested antidepressants (tricyclics, SSRIs, mirtazapine, nefazodone ) directly inhibited the metabolism of caffeine when added in vitro to liver microsomes.
Pharmacological reports : PR  •  2007  |  View Paper
Nefazodone displayed clear effect on 3-N- and 7-N-demethylation (Ki = 68.8 and 66.4 microM, respectively), but was weak in inhibiting 1-N-demethylation and 8-hydroxylation of caffeine (Ki = 110 and 186 microM, respectively).
Polish journal of pharmacology  •  2003  |  View Paper