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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Caffeine
drug:
Nefazodone
Research Papers that Mention the Interaction
“Our previous studies showed that some of the tested antidepressants (tricyclics, SSRIs, mirtazapine, nefazodone ) directly inhibited the metabolism of caffeine when added in vitro to liver microsomes.”
Caffeine metabolism during prolonged treatment of rats with antidepressant drugs.“ Nefazodone displayed clear effect on 3-N- and 7-N-demethylation (Ki = 68.8 and 66.4 microM, respectively), but was weak in inhibiting 1-N-demethylation and 8-hydroxylation of caffeine (Ki = 110 and 186 microM, respectively).”
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