Possible Interaction: Caffeine and N-Methyl-3,4-Methylenedioxyamphetamine

“Nicotine and caffeine were restricted during MDMA sessions until 8 hours after drug administration and were otherwise not allowed within 30 minutes of any measure.”

“In cytotoxicity studies, caffeine modestly enhanced the effect of MDMA on neuronal N2a cell viability but not that of liver, intestinal or kidney cells.”

“In rats, MDMA toxicity is exacerbated by co-administration of caffeine.”

“Co‐administration of caffeine profoundly enhances the acute toxicity of MDMA in rats, as manifested by high core body temperature, tachycardia and increased mortality.”

“In addition, co‐administration of caffeine enhances the long‐term serotonergic neurotoxicity induced by MDMA.”

“Although CF did not affect the uptakes of MDMA, MA, and KA, CF enhanced the permeation of MDMA in comparison to MDMA alone.”

“The area under the plasma concentration-time curve of MA significantly decreased by co-administration with KA in comparison to MA alone, while that of MDMA significantly increased by co-administration with CF in comparison to MDMA alone.”

“These findings suggest that the intestinal absorption of similar compounds with amine moieties such as MDMA, MA, and KA are mediated by a common transport system, and that CF affects the absorption of MDMA in a different way from the transport system.”

“In the present study we have examined whether the effects of MDMA on real-time stimulated dopamine release, in the absence of uptake inhibition, are accentuated in the presence of caffeine.”

“It is well documented that caffeine exacerbates the hyperthermia associated with acute exposure to 3,4-methylenedioxymethamphetamine (MDMA) in rats.”

“ Caffeine also exacerbated the oxidative damage of nuclear DNA induced by MDMA but diminished DAT decrease in the striatum and worsened a decrease in SERT density produced by MDMA in the frontal cortex.”

“ MDMA is often ingested with caffeine.”

“ MDMA is mainly consumed by adolescents, often in conjunction with caffeine (Energy Drinks) and this association has been reported to exacerbate MDMA toxic effects.”

“Administration of caffeine with 3,4-methylenedioxymethamphetamine (MDMA) alters the pharmacological properties of MDMA in rats.”

“Results suggest that the use of MDMA in association with caffeine during adolescence may exacerbate the neurotoxicity and neuroinflammation elicited by MDMA.”

“nNOS, IL‐1β, and TNF‐α were increased by MDMA in CPu of adults, whereas in adolescents, levels were only elevated after combined MDMA plus caffeine.”

“ Abstract3,4-Methylenedioxymethamphetamine (MDMA, “ecstasy”) popular as a designer drug is often used with caffeine to gain a stronger stimulant effect.”

“ Caffeine exacerbated the effect of MDMA on DA and 5-HT release.”

“Co-administration of caffeine and MDMA may aggravate MDMA-induced toxic effects on DA and 5-HT terminals.”