Possible Interaction: Caffeine and Mitoxantrone

“However, in the present study we observe that 5 mM caffeine reverses the cell kinetic and cytotoxic effects of the intercalating drug Novantrone ( mitoxantrone ) on L1210, HL‐60 and CHO cells.”

“As a consequence, caffeine treatment significantly increased the retention of an established ABCG2 substrate in MCF-7/…-7 cells and sensitized the MDR cells to the chemotherapeutic agent mitoxantrone (MX); combination treatment with MX … caffeine decreased the IC50 of MX ∼10-fold … apoptotic cell death than MX treatment alone.”

“This is published both by our and other group's data, indicates that CAF is able to modify the cytotoxic and/or cytostatic action of the two well known antitumor drugs doxorubicin (DOX) and mitoxantrone (MIT).”

“In contrast, however, the cytotoxic and cytostatic activity of aromatic, DNA-intercalating, DNA topoisomerase II inhibitors such as Adriamycin, ellipticine, or mitoxantrone are diminished in the presence of CAF.”

“In this work, we demonstrate that caffeine and other methylxanthines--pentoxifylline and theophylline--significantly decrease mutagenicity of the anticancer aromatic drugs daunomycin, doxorubicin and mitoxantrone.”